Alteration of SMAD4 does not participate in tumorigenesis of adenoid cystic carcinoma of the salivary gland.

نویسندگان

  • Tsutomu Daa
  • Naomi Yada
  • Kenji Kashima
  • Masashi Suzuki
  • Shigeo Yokoyama
چکیده

SMAD4, also known as DPC4 (deleted in pancreatic carcinoma 4) was initially identified as a tumor-suppressor gene. It is located on 18q21, a region frequently deleted in pancreatic carcinoma. Functionally inactivating mutation of the gene also occurs in many cases of pancreatic cancer. Functional loss of SMAD4 is frequently detected not only in pancreatic carcinoma but also in colorectal carcinoma. However, in other human cancers, SMAD4 aberrations are seen only occasionally. The purpose of this study was to elucidate the role of SMAD4 in adenoid cystic carcinoma of the salivary glands. We examined 34 cases of adenoid cystic carcinoma for loss of heterozygosity (LOH) of the SMAD4 locus and for the existence of mutations of the gene. LOH was detected in 2/14 informative cases. No mutations were detected in any of the 34 cases. In conclusion, the infrequent LOH of the SMAD4 gene locus and lack of SMAD4 mutations indicate that SMAD4 does not play a role in the tumorigenesis of adenoid cystic carcinoma of the salivary gland.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Immunohistochemical Expression of CD56 and ALDH1 in Common Salivary Gland Tumors

Introduction: Natural killer (NK) cells, of which CD56 is a specific marker, play an important role in host defense against tumors. Cancer stem cells, of which aldehyde dehydrogenase isoform 1 (ALDH1) is an immunohistochemical marker, are a group of tumorigenic cells which are involved in migration and tumor recurrences. We aimed to evaluate the expression of ALDH1 and CD56 in common salivary g...

متن کامل

Immunohistochemical Assessment of Ki-67 Expression in Adenoid Cystic Carcinoma of the Salivary Glands

Objective Adenoid cystic carcinoma (ACC) is a rare malignant tumor originating from the salivary glands. It’s rather bland histological appearance that masks its ultimate biological aggressiveness. Evaluation of cell cycle and mitoses have been useful in predicting malignancy in many tumors. Ki-67 antigen is a human nuclear antigen that presents during all active phases of cell cycle. The aim ...

متن کامل

بررسی تراکم ماست‌سل‌ها در شایع‌ترین تومورهای خوش‌خیم و بدخیم بزاقی در جنوب شرق ایران از سال 1384 تا 1394

Background and Objective: Salivary gland tumors are an important part of oral pathology. The role of these cells in tumorigenesis has been reported but enough investigations have not been conducted about the role of mast cells in salivary gland tumors. This research aimed to study mast cells density in the most prevalent salivary gland tumors. Materials and Methods: In this cross-sectional s...

متن کامل

بررسی ارزش رنگ آمیزی (Phosphotungstic Acid Haematoxylin (PTAH در تشخیص افتراقی تومورهای غدد بزاقی

The differential diagnosis between pleomorphic adenoma, the most common salivary gland neoplasm, microscopically, and two other common salivary gland neoplasms, meaning adenoid cystic carcinoma and mucoepidermoid carcinoma, is difficut.The purpose of this study was to determine the differences between pleomorphic adenoma, adenoid cystic carcinoma and mucoepidermoid carcinoma regarding the stain...

متن کامل

MTA1 Expression in Benign and Malignant Salivary gland Tumors

Introduction: Salivary gland tumors (SGTs) are important parts of human neoplasms. The most common SGT is pleomorphic adenoma and the most common malignant SGTs are mucoepidermoid carcinoma and adenoid cystic carcinoma (ACC). Metastasis-associated genes 1 (MTA1), a member of the nucleosome remodeling and histone deacetylation complex, is one newly discovered gene which recruits histone deacetyl...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Molecular medicine reports

دوره 2 1  شماره 

صفحات  -

تاریخ انتشار 2009